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KMID : 0358320070480030244
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Korean Journal of Urology
2007 Volume.48 No. 3 p.244 ~ p.251
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The Relationship of Clusterin Expression with Ki-67 Expression and Clinicopathological Factors in Human Renal Cell Carcinoma
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Park Hyun-Cheol
Lee Wan
Lee Sang-Don
Kim Jung-Man
Lee Chang-Yell
Lee Jeong-Zoo
Chung Moon-Kee
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Abstract
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Purpose: This study was performed to evaluate the relationship of the expressions of clusterin with Ki-67 and the clinicopathological factors and significance of clusterin expression in human renal cell carcinoma(RCC).
Materials & Methods: Normal kidney(n=26) and RCC tissues(n=111) were obtained from 111 patients who had undergone a radical or partial nephrectomy. The expressions of clusterin and Ki-67 protein were analysed using immunohistochemical staining. The medical records of the patients were retrospectively reviewed to evaluate the clinicopathological factors.
Results: In contrast to the clusterin and Ki-67 expressions of 30.8 and 11.5%, respectively in the normal kidney(n=26), those in the RCC tissues were 93.7 and 28.8%(n=111), respectively(p＜0.05). In contrast to the normal tissues, Ki-67 staining was significantly correlated with the expression of clusterin in the RCC tissues(p＜0.05). The expression level of clusterin protein in the RCC tissues was significantly related to the tumor stage and grade(p＜0.05), but not to age, gender or histological cell type(p＞0.05). Furthermore, the recurrence-free survival in patients with strong clusterin expression was significantly lower than in those with weak expression(p＜0.05).
Conclusion: These findings suggest that clusterin may be involved in the progression of RCC and; therefore, a useful prognostic variable in patients with an RCC.(Korean J Urol 2007;48:244-251)
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KEYWORD
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Renal cell carcinoma, Clusterin, Ki-67 antigen, Clinicopathological factor
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